MIXED SLEEP APNEA
As the name suggests, mixed sleep apnea is when an individual suffers from a combination of both Obstructive Sleep Apnea (OSA) and Central Sleep Apnea (CSA). In most cases the patient will start by suffering with central type of sleep apnea and then it becomes an obstructive type. Research has shown that the central aspect of this apnea automatically reduces once the obstructive component is treated usually with the help of a continuous positive airway pressure (CPAP) machine.
Although central sleep apnea can strike just about anyone at any age, the usual patient is an overweight male of forty years of age or older.
We can now determine that a shift from central and mixed sleep apnea to obstructive sleep apnea results from low-flow oxygen. Although this is a fairly technical explanation we wanted to include it in this page as we want to give our readers as much information about deprivation of sleep as possible:
Low-flow oxygen decreases the frequency of the 3 types of apnea (central, mixed, and obstructive) in patients with predominantly obstructive sleep apnea. The decrease in frequency appears to be accompanied by a shift in apnea distribution, consisting of a decrease in the proportion of central and mixed apneas and an increase in that of obstructive apneas. To determine whether this shift represents a greater inhibitory effect on central and mixed apneas or an increased tendency toward obstructive apneas, we administered low-flow oxygen during sleep to 9 patients who demonstrated predominantly central and mixed sleep apnea (51 +/- 33% and 33 +/- 21% of apneic events, respectively, mean +/- SD) and had resting, room air, oxygen tensions of 83 +/- 11 mmHg. During non-REM sleep, oxygen increased the baseline oxyhemoglobin saturation while reducing the average peak fall in oxyhemoglobin saturation during each apneic event. Oxygen reduced the overall apnea frequency from 66 +/- 7.8 (mean +/- SE) to 43.0 +/- 10.7 episodes per hour (p less than 0.02). Central and mixed apneas decreased markedly from 31.4 +/- 0.6 to 6.4 +/- 4.3 episodes per hour (p less than 0.02) and from 20.9 +/- 5.0 to 4.9 +/- 1.5 episodes per hour (p less than 0.02), respectively. However, obstructive apnea frequency more than doubled from 13.9 +/- 7.0 to 32.1 +/- 9.2 episodes per hour (p less than 0.02). We conclude that in these patients oxygen tension altered both the frequency and distribution of sleep-induced apnea, with a lower oxygen tension increasing the frequency of central and mixed apneas and a higher oxygen tension increasing the frequency of obstructive apneas.
From: http://www.ncbi.nlm.nih.gov/pubmed/4026046, Gold AR, Bleecker ER, Smith PL.
deprivation of sleep |
sleep apnea |
what is sleep apnea |
obstructive sleep apnea |
central sleep apnea |
mixed sleep apnea